Polycystin-2 Immunolocalization and Function in Zebrafish

Polycystin - 1 and Polycystin - 2 Complexes

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Earlier work has shown that PC1 and PC2 assemble into a polycystin complex implicated in kidney morphogenesis. PC2 also assembles into homomers of uncertain functional significance. However, little is known about the molec...

Polycystin: From structure to function

Autosomal dominant polycystic kidney disease ceptor tyrosine kinase inhibitors failed to block cAMP(ADPKD) is a multisystem disease characterized by the mediated proliferation of tubular cells from ADPKD progressive development of numerous fluid-filled cysts patients. These studies indicate that cAMP agonists stimin the kidney, leading to chronic renal failure. Predomiulate PKA-mediated activat...

Vascular expression of polycystin-2.

The expression of polycystin-1 in the vascular smooth muscle cells (VSMC) of elastic and large distributive arteries suggests that some vascular manifestations of autosomal-dominant polycystic kidney disease (ADPKD) result directly from the genetic defect. Intracranial aneurysms have been reported in PKD2, as well as in PKD1 families. To determine whether the vascular expression of polycystin-2...

Distribution and function of polycystin-2 in mouse retinal ganglion cells.

The polycystin family of transient receptor potential (TRP) channels form Ca(2+) regulated cation channels with distinct subcellullar localizations and functions. As part of heteromultimeric channels and multi-protein complexes, polycystins control intracellular Ca(2+) signals and more generally the translation of extracellular signals and stimuli to intracellular responses. Polycystin-2 channe...